朱久新, 副教授,从事心脑血管药理学及转化医学研究，致力于心血管药物和抗肿瘤药物研发。

【研究工作经历】

2014/08-至今，15vip太阳集团，15vip太阳集团，药理教研室，副教授

2010/10-2014/07，15vip太阳集团，15vip太阳集团，药理教研室，讲师

2007.01 ~ 2009.01日本三和化学研究所，药物研究实验室，研究学者

2007/07-2010/09，15vip太阳集团，15vip太阳集团，药理教研室，助教

【科研项目】

1.国家自然科学基金，81401540，靶向载姜黄素脂质微泡用于声光

动力联合对肝癌的作用及机制研究，2015-2017，23万，在研，参加

2. 国家自然科学基金，81370244，新型内源性心肌保护分子Betaglycan分子调控网络及其外源融合肽干预研究，2014-2017，80万，在研，参加

3. 黑龙江省自然科学基金项目青年基金，QC2013C077，同型半胱氨酸诱导心肌肥厚和纤维化的microRNA机制，2014-2016，5万，已结题，主持

4. 国家自然科学基金，30871227，调控雌性SD大鼠Ah-型压力感受器神经元兴奋性的离子通道机制，2011-2013，60万，已结题，参加

5. 国家自然科学基金，30971252，miR-328和miR-433加重心肌损伤的机制及"一药多靶"心肌保护治疗探索，2009-2011，31万，已结题，参加

【主要论著】

(1) Zhu J, Xie R, Piao X, Hou Y, Zhao C, Qiao G, Yang B, Shi J, Lu Y. Homocysteine enhances clot-promoting activity of endothelial cells via phosphatidylserine externalization and microparticles formation. Amino Acids 2012;43(3):1243-50.

(2)Xu B, Zhu JX, Huo R, Yan ZY, He JL, Deng L, Wang JX, He J, Qiao GF, ChenH, Li BY. Alternations of cardiac IK1 and Ito from FKBP12.6 transgenic mouse heart and potential impact of cardiac hypertrophy. Int J Cardiol. 2014 Oct 20;176(3):1017-20.

(3)Sun B, Huo R, Sheng Y, Li Y, Xie X, Chen C, Liu HB, Li N, Li CB, Guo WT, Zhu JX, Yang BF, Dong DL. Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy. Hypertension. 2013;61(2):352-60.

(4)Xie R, Gao C, Li W, Zhu J, Novakovic V, Wang J, Ma R, Zhou J, Gilbert GE, Shi J . Phagocytosis by macrophages and endothelial cells inhibits procoagulant and fibrinolytic activity of acute promyelocytic leukemia cells. Blood 2012;119(10):2325-34.

(5) Chu W, Wan L, Zhao D, Qu X, Cai F, Huo R, Wang N, Zhu J, Zhang C, Zheng F, Cai R, Dong D, Lu Y, Yang B. Mild hypoxia-induced cardiomyocyte hypertrophy via up-regulation of HIF-1α-mediated TRPC signalling. J Cell Mol Med. 2012;16(9):2022-34.

(6) Li Q, Zhang Y, Sheng Y, Huo R, Sun B, Teng X, Li N, Zhu JX, Yang BF, Dong DL. Large T-antigen up-regulates Kv4.3 K⁺ channels through Sp1, and Kv4.3 K⁺ channels contribute to cell apoptosis and necrosis through activation of calcium/calmodulin-dependent protein kinase II. Biochem J. 2012;441(3):859-67.

(7) Yang Y, Piao X, Zhang M, Wang X, Xu B, Zhu J, Fang Z, Hou Y, Lu Y, Yang B. Bioactivity-guided fractionation of the triglyceride-lowering component and in vivo and in vitro evaluation of hypolipidemic effects of Calyx seu Fructus Physalis. Lipids Health Dis. 2012;11:38.

(8) Bai YL, Liu HB, Sun B, Zhang Y, Li Q, Hu CW, Zhu JX, Gong DM, Teng X, Zhang Q, Yang BF, Dong DL. HIV Tat protein inhibits hERG K+ channels: a potential mechanism of HIV infection induced LQTs. J Mol Cell Cardiol. 2011;51(5):876-80.

(9) Fukaya N, Mochizuki K, Tanaka Y, Kumazawa T, Jiuxin Z, Fuchigami M, Goda T. The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats. Eur J Pharmacol. 2009;624(1-3):51-7.

(10) Kumazawa T, Nakajima A, Ishiguro T, Jiuxin Z, Tanaharu T, Nishitani H, Inoue Y, Harada S, Hayasaka I, Tagawa Y. Collaborative work on evaluation of ovarian toxicity. 15) Two- or four-week repeated-dose studies and fertility study of bromocriptine in female rats. J Toxicol Sci. 2009;34 Suppl 1:SP157-65.